1-Isothiocyanato-2-methylbutane → HCID 21999995, compound

HRID 1975918Notes

Reaction equation

HRID 1975918 reaction equation
Cl.[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH3:13][CH:14]([CH2:19][CH3:20])[CH2:15][N:16]=[C:17]=[S:18]>>[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH:12][C:17]([NH:16][CH2:15][CH:14]([CH3:13])[CH2:19][CH3:20])=[S:18])(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 1382251-Isothiocyanato-2-methylbutaneHCID 688206263-Amino-5-chlorothiophene-2-sulfonamide hydrochloride

Product 1

HCID 21999995HCID 21999995, compound

Procedure

The title compound was prepared from 3-amino-5-chlorothiophene-2-sulfonamide hydrochloride and 2-methylbutyl isothiocyanate by a procedure analogous to the procedure described in example 3-a (yield 28%); mp 116.5-118° C., 1H-NMR (DMSO-d6): δ0.8 (2 d, 6H, 2×CH3), 1.10 (m, 1H), 1.30 (m, 1H), 1.65 (m, 1H), 3.40 (m, 2H+HDO, CH2), 6.45 (br, 2H, NH2), 6.65 (s, 1H, H-4), 8.25 (br t, 1H, NH), 11.3 (br s, 1H).

Sources & evidence

ORD record
ord-749c2b46276e43188e510b595973cbe6
Source dataset
uspto-grants-2001_05
Patent number
US06225310B1

Reaction notes

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