2-(Isothiocyanatomethyl)furan → N-(3-Amino-5-chloro-2-thienylsulfonyl)-N'-(furan-2-ylmethyl)thiourea

HRID 1975937Notes

Reaction equation

HRID 1975937 reaction equation
Cl.[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH2:13]([N:19]=[C:20]=[S:21])[C:14]1[O:18][CH:17]=[CH:16][CH:15]=1>>[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH:12][C:20]([NH:19][CH2:13][C:14]1[O:18][CH:17]=[CH:16][CH:15]=1)=[S:21])(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 783802-(Isothiocyanatomethyl)furanHCID 688206263-Amino-5-chlorothiophene-2-sulfonamide hydrochloride

Product 1

HCID 21999996N-(3-Amino-5-chloro-2-thienylsulfonyl)-N'-(furan-2-ylmethyl)thiourea

Procedure

The title compound was prepared from 3-amino-5-chlorothiophene-2-sulfonamide hydrochloride and furfuryl isothiocyanate by a procedure analogous to the procedure described in example 3-a (yield of crude product: 92%).

Sources & evidence

ORD record
ord-07ccfc35597f4848a925dd010fa4f4fb
Source dataset
uspto-grants-2001_05
Patent number
US06225310B1

Reaction notes

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