2-Naphthoyl chloride → HCID 22721826, compound

HRID 1975994Notes

Reaction equation

HRID 1975994 reaction equation
[NH2:1][CH:2]([C:19]([N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:20])[CH2:3][NH:4][C:5]([CH:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)=[O:6].[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[C:37](Cl)=[O:38]>>[N:21]1([C:19]([CH:2]([NH:1][C:37]([C:28]2[CH:29]=[CH:30][C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH:27]=2)=[O:38])[CH2:3][NH:4][C:5]([CH:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)=[O:6])=[O:20])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 22721868HCID 22721868, compound

Product 1

HCID 22721826HCID 22721826, compoundYield 85%

Procedure

Using an analogous procedure to that described in Example 2, N-[2-amino-2-(piperidinocarbonyl)ethyl]-1-(4-pyridyl)piperidine-4-carboxamide was reacted with naphthalene-2-carbonyl chloride to give N-{1-(piperidinocarbonyl)-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]-ethyl}naphthalene-2-carboxamide in 85% yield;

Sources & evidence

ORD record
ord-94e3be4ef33540798af573bc3f7c006b
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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