N-(3-Aminopropyl)-2-naphthalenesulfonamide → HCID 22721870, compound

HRID 1975996Notes

Reaction equation

HRID 1975996 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14](Cl)=[O:15])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[NH2:17][CH2:18][CH2:19][CH2:20][NH:21][S:22]([C:25]1[CH:34]=[CH:33][C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=1)(=[O:24])=[O:23]>>[CH:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:33]=[CH:34][C:25]=1[S:22]([NH:21][CH2:20][CH2:19][CH2:18][NH:17][C:14](=[O:15])[CH2:13][N:10]1[CH2:11][CH2:12][N:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:8][CH2:9]1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 22721759N-(3-Aminopropyl)-2-naphthalenesulfonamideHCID 22721872HCID 22721872, compound

Product 1

HCID 22721870HCID 22721870, compoundYield 34%

Procedure

Using an analogous procedure to that described in Example 1, 2-[4-(4-pyridyl)piperazin-1-yl]acetyl chloride was reacted with N-(3-aminopropyl)naphthalene-2-sulphonamide to give N-[3-(2-naphthalene-sulphonamido)propyl]-2-[4-(4-pyridyl)piperazin-1-yl]acetamide in 34% yield;

Sources & evidence

ORD record
ord-2fe8a712bc6145bd94fc060a9e441989
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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