tert-butyl N-(pyrrolidin-3-yl)carbamate → HCID 22721807, compound

HRID 1976000Notes

Reaction equation

HRID 1976000 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:28][CH2:27][NH:26][CH2:25]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:28][CH2:27][N:26]([C:13]([CH:10]2[CH2:11][CH2:12][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:8][CH2:9]2)=[O:14])[CH2:25]1)=[O:22])([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

Product 1

HCID 22721807HCID 22721807, compoundYield 41%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with 3-(tert-butoxycarbonylamino)pyrrolidine to give 3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]pyrrolidine in 41% yield.

Sources & evidence

ORD record
ord-1585ee6a24334ba684cee770b4795b13
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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