2-Naphthalenesulfonyl chloride → Methyl 4-[(2-naphthalenylsulfonyl)amino]butanoate

HRID 1976007Notes

Reaction equation

HRID 1976007 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[NH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 18614Methyl 4-aminobutanoate

Product 1

HCID 4204457Methyl 4-[(2-naphthalenylsulfonyl)amino]butanoateYield 94%

Procedure

Using an analogous procedure to that described in Example 2, 2-naphthylsulphonyl chloride was reacted with methyl 4-aminobutyrate to give methyl 4-(2-naphthalenesulphonamido)butyrate in 94% yield.

Sources & evidence

ORD record
ord-da6a789ab1d84552bf50275260d3052b
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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