1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721940, compound

HRID 1976010Notes

Reaction equation

HRID 1976010 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[S:26]([N:29]1[CH2:34][CH2:33][NH:32][CH:31]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:30]1)(=[O:28])=[O:27]>>[CH2:38]([O:37][C:35]([CH:31]1[CH2:30][N:29]([S:26]([C:17]2[CH:18]=[CH:19][C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=2)(=[O:27])=[O:28])[CH2:34][CH2:33][N:32]1[C:13]([CH:10]1[CH2:11][CH2:12][N:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:8][CH2:9]1)=[O:14])=[O:36])[CH3:39]

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721891HCID 22721891, compound

Product 1

HCID 22721940HCID 22721940, compoundYield 9%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with ethyl 1-(2-naphthylsulphonyl)piperazine-3-carboxylate to give 2-ethoxycarbonyl-4-(2-naphthylsulphonyl)-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine as a glassy solid in 9% yield;

Sources & evidence

ORD record
ord-71dc56b3d03644d4a11ce9173b058710
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

Loading…