HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → 1-(2-Naphthylmethyl)-2-oxo-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Reactant | 1-(2-Naphthylmethyl)-2-oxopiperazine trifluoroacetate salt | HCID 22721829 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-Naphthylmethyl)-2-oxo-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]-piperazine | HCID 22721778 | 18% |
Reaction Steps
Using an analogous procedure to that described in Example 1 except that DMF was used in place of methylene chloride as the reaction solvent, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with 1-(2-naphthylmethyl)-2-oxopiperazine trifluoroacetate salt to give 1-(2-naphthylmethyl)-2-oxo-4-[-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine in 18% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225309B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-da36f2daa1bf4b60963d04dc4d10b2a3 |
| Source note | uspto-grants-2001_05 |