1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721919, compound

HRID 1976021Notes

Reaction equation

HRID 1976021 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([S:29]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)(=[O:31])=[O:30])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>>[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([S:29]([N:32]3[CH2:37][CH2:36][N:35]([C:13]([CH:10]4[CH2:11][CH2:12][N:7]([C:4]5[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=5)[CH2:8][CH2:9]4)=[O:14])[CH2:34][CH2:33]3)(=[O:31])=[O:30])=[CH:27][CH:28]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721761HCID 22721761, compound

Product 1

HCID 22721919HCID 22721919, compoundYield 67%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with 1-(4′-methylbiphenyl-4-ylsulphonyl)piperazine to give 1-(4′-methylbiphenyl-4-ylsulphonyl)-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine in 67% yield, m.p. 213-217° C.;

Sources & evidence

ORD record
ord-948b3c24dec84d2d9daf43df0b40612f
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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