HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate → 4-(6-Chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate | HCID 10970999 | — |
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Product | 4-(6-Chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine | HCID 22721818 | 37% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate to give 4-(6-chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)-piperidin-4-ylcarbonyl]piperazine in 37% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225309B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-19711aadc7754126a4516e719ba019b1 |
| Source note | uspto-grants-2001_05 |