HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride → 2-[(E)-4-chlorostyrylsulphonamido]-N-[1-piperidinocarbonyl-2-{1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride | HCID 5938154 | — |
| Reactant | 2-amino-N-{l-piperidinocarbonyl-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide hydrochloride salt | HCID 21999976 | — |
| Product | 2-[(E)-4-chlorostyrylsulphonamido]-N-[1-piperidinocarbonyl-2-{1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide | HCID 22721931 | 16% |
Reaction Steps
Using an analogous procedure to that described in Example 2, 2-amino-N-{1-piperidinocarbonyl-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide hydrochloride salt was reacted with (E)-4-chlorostyrylsulphonyl chloride to give 2-[(E)-4-chlorostyrylsulphonamido]-N -[1-piperidinocarbonyl-2-{1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide as a gum (0.1 g, 16%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225309B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-df2401f17e744538adfcee4d549db304 |
| Source note | uspto-grants-2001_05 |