1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721908, compound

HRID 1976031Notes

Reaction equation

HRID 1976031 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[OH:16][CH2:17][CH:18]1[CH2:23][N:22]([S:24]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)(=[O:26])=[O:25])[CH2:21][CH2:20][NH:19]1>>[OH:16][CH2:17][CH:18]1[CH2:23][N:22]([S:24]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)(=[O:26])=[O:25])[CH2:21][CH2:20][N:19]1[C:13]([CH:10]1[CH2:11][CH2:12][N:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:8][CH2:9]1)=[O:14]

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721864HCID 22721864, compound

Product 1

HCID 22721908HCID 22721908, compoundYield 42%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with 2-hydroxymethyl-4-(2-naphthylsulphonyl)piperazine to give 2-hydroxymethyl-4-(2-naphthylsulphonyl)-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine in 42% yield;

Sources & evidence

ORD record
ord-3b9dde27c7d44e548cf2d26da7e7031d
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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