1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721911, compound

HRID 1976033Notes

Reaction equation

HRID 1976033 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[S:26]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH:30]1[CH2:35][C:36]([O:38][CH3:39])=[O:37])(=[O:28])=[O:27]>>[CH3:39][O:38][C:36]([CH2:35][CH:30]1[CH2:31][N:32]([C:13]([CH:10]2[CH2:11][CH2:12][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:8][CH2:9]2)=[O:14])[CH2:33][CH2:34][N:29]1[S:26]([C:17]1[CH:18]=[CH:19][C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:16]=1)(=[O:27])=[O:28])=[O:37]

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721844HCID 22721844, compound

Product 1

HCID 22721911HCID 22721911, compoundYield 90%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with methyl 2-[1-(2-naphthylsulphonyl)piperazin-2-yl]acetate to give 2-methoxycarbonylmethyl-1-(2-naphthylsulphonyl)-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine in 90% yield as a glass;

Sources & evidence

ORD record
ord-45d19b7f346345149c41fb8afc876a62
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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