6-Bromonaphthalene-2-sulfonyl chloride → HCID 22721859, compound

HRID 1976041Notes

Reaction equation

HRID 1976041 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[O:8])[CH2:3][CH2:2]1.[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]=[C:27]([S:32](Cl)(=[O:34])=[O:33])[CH:26]=[CH:25]2>>[Br:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[CH:28]=[C:27]([S:32]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([N:9]3[CH2:14][CH2:13][N:12]([C:15]4[CH:16]=[CH:17][N:18]=[CH:19][CH:20]=4)[CH2:11][CH2:10]3)=[O:8])[CH2:3][CH2:2]1)(=[O:34])=[O:33])[CH:26]=[CH:25]2

Participants

3

Reactant 2

HCID 144577416-Bromonaphthalene-2-sulfonyl chlorideHCID 22721924HCID 22721924, compound

Product 1

HCID 22721859HCID 22721859, compoundYield 20%

Procedure

Using an analogous procedure to that disclosed in Example 2, 1-(4-piperidinylcarbonyl)-4-(4-pyridyl)piperazine was reacted with 6-bromonaphth-2-ylsulphonyl chloride to give 1-[1-(6-bromonaphth-2-ylsulphonyl)piperidin-4-ylcarbonyl]-4-(4-pyridyl)piperazine in 20% yield, m.p. 229-230° C.;

Sources & evidence

ORD record
ord-363f2d2890cd45cb8ede2132e42ce6da
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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