Nitric Acid → 2-Bromo-3-methoxy-6-nitropyridine

Participants

Reaction Conditions

Reaction Steps

2-Bromo-3-methoxypyridine (Desc. 4; 12.4 g, 66 mmol) in concentrated sulphuric acid (30 ml) was treated dropwise with fuming nitric acid (5.5 ml), and the solution heated at 60° C. for 2 hours. After cooling the solution was poured onto ice (500 ml). The solid formed was recovered by filtration, washed with water (500 ml) and sodium bicarbonate solution (500 ml) to give the title product as a yellow solid (10.0 g, 43 mmol, 65% yield).

Provenance & Evidence