HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3-methoxy-6-nitropyridine → 6-Bromo-5-methoxypyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3-methoxy-6-nitropyridine | HCID 12692873 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum dioxide monohydrate | HCID 11139377 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Bromo-5-methoxypyridin-2-amine | HCID 12758209 | 99% |
Reaction Steps
2-Bromo-3-methoxy-6-nitropyridine (Desc. 5; 9.0 g, 38.6 mmol) and platinum (IV) oxide hydrate (250 mg) in ethyl acetate (250 ml) was hydrogenated at 20 psi hydrogen for 1 hour. The catalyst was removed by filtration and the filtrate concentrated to give the product as a yellow solid (7.73 g, 38.1 mmol, 99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225320B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-d63e63c2ed3f42fd91b928ddaf532fa1 |
| Source note | uspto-grants-2001_05 |