Bromine → HCID 178517749, compound

Participants

Reaction Conditions

Reaction Steps

5-Trifluoromethyl-2(1H)-pyridone (10.0 g) and sodium acetate (5.25 g, 64 mmol) in acetic acid (100 ml) was treated with bromine (3.3 ml, 63 mmol) and heated at 80° C. for 2 hrs, before being cooled and concentrated. The residue was basified with sodium hydrogen carbonate solution (250 ml) and extracted with ethyl acetate (2×250 ml). The extracts were dried (MgSO4) and concentrated to give the product as a tan solid (14.22 g, 96% yield).

Provenance & Evidence