Methanol → HCID 22000205, compound

Participants

Reaction Steps

3-Bromo-2-chloro-5-(2-trifluoromethylimidazol-1-yl)pyridine (318 mg, 0.97 mmol) in methanol (12 ml) was treated with sodium hydride (54 mg, 60% dispersion in oil, 1.41 mmol) and refluxed for 3 hrs. After cooling and concentration, the residue was purified by silica chromatography, to give the product as a yellow solid (252 mg, 80% yield).

Provenance & Evidence