反应详情

To a suspension of 3-bromo-5-trifluoromethyl-2(1H)-pyridone (2.0 g, 8.26 mmol) and silver carbonate (2.32 g, 8.4 mmol) in hexane (50 mL) was added iodomethane (1.05 mL, 16.8 mmol) and the resulting mixture heated at reflux for 16 hrs. The suspension was cooled, and filtered, and the filtrate concentrated in vacuo. The residue was purified by silica chromatography to give the product as an oil (893 mg, 3.49 mmol, 42% yield).

1. temperaturethe resulting mixture heated
2. temperatureat reflux for 16 hrs
3. temperatureThe suspension was cooled
4. filtrationfiltered
5. concentrationthe filtrate concentrated in vacuo
6. customThe residue was purified by silica chromatography