HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-3-nitro-6-(trifluoromethyl)pyridine → 2-Chloro-6-(trifluoromethyl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-3-nitro-6-(trifluoromethyl)pyridine | HCID 10799293 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Chloro-6-(trifluoromethyl)pyridin-3-amine | HCID 2737646 | 100% |
Reaction Steps
2-Chloro-3-nitro-6-trifluoromethylpyridine (22.7 g, 0.10 mol) and platinum(IV) oxide (500 mg) in ethyl acetate (500 ml) were hydrogenated at 20 psi hydrogen for 2 hrs, then the catalyst was removed by filtration. The filtrate was concentrated to give the product as a tan solid (19.5 g, 0.1 mol, 99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225320B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-023a0347fa7f4a33bf479b1faf426aae |
| Source note | uspto-grants-2001_05 |