HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 5-Amino-2-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-Chloro-6-(trifluoromethyl)pyridin-3-amine | HCID 2737646 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-2-(trifluoromethyl)pyridine | HCID 2737744 | 92.1% |
Reaction Steps
3-Amino-2-chloro-6-trifluoromethylpyridine (15.0 g, 76 mmol), sodium acetate (12.53 g, 153 mmol) and 10% palladium on carbon (1.5 g) in methanol (300 ml) were hydrogenated at 50 psi hydrogen for 18 h, then the suspension was filtered. The filtrate was concentrated to give the product as a tan solid (11.38 g, 70 mmol, 92% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225320B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-f9d3b9e44e944f889704e0cd0e48c9b4 |
| Source note | uspto-grants-2001_05 |