HCID 23447583, compound → HCID 22000251, compound

Participants

Reaction Steps

A solution of 1-(6-chloropyrimidin-4-yl)-4-piperidone ethylene ketal (2 g, 8.87 mmol) in ethanol (25 ml) and ethyl acetate (25 ml) was hydrogenated at 60 psi for 1 hr over 10% Pd/C (0.25 g). The mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in methylene chloride and filtered through celite. The filtrate was concentrated in vacuo to give 1-(pyrimidin-4-yl)-4-piperidone ethylene as a white solid (112-115° C.).

Provenance & Evidence