HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1976181Generated: November 1, 2026
5-Methyl-2-thiophenecarboxaldehyde → 3-[(2-Methylthien-5-yl)methylene]-2-indolinone
https://huagongshe.com/reaction/1976181
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Methyl-2-thiophenecarboxaldehyde | HCID 61663 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(2-Methylthien-5-yl)methylene]-2-indolinone | HCID 4374890 | 99% |
Reaction Steps
A reaction mixture of 134.0 mg of oxindole, 151.42 mg of the 5-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 237.8 mg (99%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06225335B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-a2e12dcac9f1401aadeed37f59e9470e |
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| Source note | uspto-grants-2001_05 |
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