3,5-Dimethyl-4-hydroxybenzaldehyde → (E)-3-(3,5-Dimethyl-4-hydroxyphenyl)-2-[(pyrid-2-yl)sulfonyl]acrylonitrile

HRID 1976190Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:11])[C:9]=1[OH:10])[CH:5]=O.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[S:18]([CH2:21][C:22]#[N:23])(=[O:20])=[O:19]>>[CH3:1][C:2]1[CH:3]=[C:4](/[CH:5]=[C:21](/[S:18]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=2)(=[O:20])=[O:19])\[C:22]#[N:23])[CH:7]=[C:8]([CH3:11])[C:9]=1[OH:10]

Participants

Reactant 2

HCID 752223,5-Dimethyl-4-hydroxybenzaldehyde

HCID 5193552-Pyridinesulfonylacetonitrile

Product 1

HCID 9944672(E)-3-(3,5-Dimethyl-4-hydroxyphenyl)-2-[(pyrid-2-yl)sulfonyl]acrylonitrile

Procedure

The titled compound was prepared with 3,5-dimethyl-4-hydroxybenzaldehyde and (pyrid-2-yl)sulphonyl acetonitrile under the similar conditions as described for EXAMPLE 1.

Sources & evidence

ORD record: ord-ae4b053adc6940e79cf7b5ff860da788
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06225346B1

Reaction notes

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