Potassium Carbonate → HCID 22000664, compound

Participants

Reaction Steps

2-Methyl resorcinol (0.07 g, 0.59 mmol), 4-bromomethyl-1,3-dimethoxybenzene (0.13 g, 0.55 mmol), potassium carbonate (0.09 g, 0.68 mmol) and 18-crown-6-ether (0.03 g, 0.11 mmol) were combined in acetone (15 cm3, 99%) and heated to reflux under nitrogen for 22 hours. The solution was evaporated under reduced pressure, and the residue was taken up in dichloromethane (10 cm3) and water (10 cm3). The aqueous layer was extracted with dichloromethane (2×10 cm3), and the combined extracts were washed with water (2×20 cm3), dried (MgSO4), and evaporated under reduced pressure. The residue was chromatographed (SiO2, dichloromethane) to give the phenol, (0.02 g, 15%), as a white solid, mp 63-69° C.

Provenance & Evidence