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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1976222Generated: October 26, 2026

1-Fluoro-2-nitrobenzene → (2R,4R)-4-Hydroxy-1-(2-Nitrophenyl) Proline Methyl Ester

https://huagongshe.com/reaction/1976222

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Fluoro-2-nitrobenzeneHCID 73895—
ReactantMethyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochlorideHCID 12764090—
Product(2R,4R)-4-Hydroxy-1-(2-Nitrophenyl) Proline Methyl EsterHCID 1204275597.2%

Reaction Steps

The same procedures used in Reference Example 1 were repeated except for using the cis-4-hydroxy-D-proline methyl ester hydrochloride prepared in Reference Example 4 and 1-fluoro-2-nitrobenzene to give the title compound. Yield 97.2%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06225306B1
Source datasetuspto-grants-2001_05
ORD IDord-fe8e67588dba4de8b9829f76870ea5f9
Source noteuspto-grants-2001_05