HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isatoic Anhydride → (11aR)-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5,11-Dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | D-Proline | HCID 8988 | — |
| Product | (11aR)-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5,11-Dione | HCID 677115 | 78.9% |
Reaction Steps
The same procedures used in the method B in Reference Example 19 were repeated except for the use of isatoic anhydride and D-proline to form the title compound. Yield 78.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225306B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-bc3439b5ae454d738203c6c8c0964cfb |
| Source note | uspto-grants-2001_05 |