L-Hydroxyproline → HCID 2755917, compound

Participants

Reaction Conditions

Reaction Steps

Isatoic anhydride (3.5 g) and trans-4-hydroxy-L-proline (2.8 g) were suspended in 60 ml of dimethyl sulfoxide and the suspension was heated with stirring at 120° C. for 2 hours. After allowing the reaction liquid to cool, the solvent was distilled off under reduced pressure and the resulting residue was washed with ethyl acetate and dried. The crude crystals were recrystallized from ethanol to give 3.9 g (yield 78.5%) of the title compound.

Provenance & Evidence