HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylene Oxide → Cis-4-Hydroxy-D-Proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride | HCID 12310682 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Cis-4-Hydroxy-D-Proline | HCID 440014 | 85.4% |
Reaction Steps
To a solution of 4.5 g of cis-4-hydroxy-D-proline hydrochloride in 300 ml of ethanol, there was added 13.1 g of propylene oxide at room temperature and then the mixture was heated under refluxing for one hour. After allowing the reaction liquid to cool, the crystals precipitated were filtered off, washed with ethanol and then dried to give 3.0 g (yield 85.4%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225306B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-3f26763b80a24a19a92ac78a613c5999 |
| Source note | uspto-grants-2001_05 |