HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[[2-(4-Tolyl)benzoyl)amino]benzoic acid → (2R,3aS)-2-Hydroxy-5-[4-[[2-(4-Tolyl)Benzoyl] Amino]Benzoyl]-1,2,3,3a,4,5-Hexahydro-Pyrrolo[1,2-a]Quinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[[2-(4-Tolyl)benzoyl)amino]benzoic acid | HCID 15545382 | — |
| Reactant | (2R,3aS)-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoxalin-2-ol | HCID 15545386 | — |
| Product | (2R,3aS)-2-Hydroxy-5-[4-[[2-(4-Tolyl)Benzoyl] Amino]Benzoyl]-1,2,3,3a,4,5-Hexahydro-Pyrrolo[1,2-a]Quinoxaline | HCID 12042759 | 55% |
Reaction Steps
The same procedures used in Example 1 were repeated using (2R, 3aS)-2-hydroxy-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoxaline prepared in Reference Example 16 and 4-[[2-(4-tolyl)benzoyl]amino]benzoic acid to give the title compound after recrystallization from ethyl acetate-hexane. m.p.: 163-164.5° C.; Yield 55.0%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225306B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-0d13d1865ddc4ef9877640f83064e779 |
| Source note | uspto-grants-2001_05 |