Hydrazine hydrate (1:1) → HCID 59954338, compound

Participants

Reaction Steps

Hydrazine monohydrate (0.41 g) was added to a solution of (2S, 3aS)-5-[4-[(2-phenylbenzoyl)amino]benzoyl]-2-phthalimido-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoxaline (1.0 g) prepared in Reference Example 65 in ethanol (10 ml) and the mixture was heated under reflux conditions for one and half hours. After cooling the reaction solution, the ethanol was removed through concentration. The resulting residue was dissolved in chloroform, the resulting solution was washed with a 5% aqueous solution of sodium hydroxide and water, died over anhydrous magnesium sulfate and then concentrated. The resulting residue was subjected to silica gel column chromatography and then eluted with chloroform/methanol (95/5) to give 0.68 g (yield 86.0%) of the title compound as amorphous powder.

Provenance & Evidence