HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[[2-(4-Tolyl)benzoyl)amino]benzoic acid → (11aS)-10-[4-[[2-(4-Tolyl) Benzoyl]Amino]Benzoyl]-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[[2-(4-Tolyl)benzoyl)amino]benzoic acid | HCID 15545382 | — |
| Reactant | (11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one | HCID 44430444 | — |
| Product | (11aS)-10-[4-[[2-(4-Tolyl) Benzoyl]Amino]Benzoyl]-1,2,3,10,11,11a-Hexahydro-5H-Pyrrolo[2,1-c][1,4]Benzodiazepin-5-One | HCID 20651216 | 74.4% |
Reaction Steps
The same procedures used in Example 25 were repeated using (11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one prepared in Reference Example 24 and 4-[[2-(4-tolyl)benzoyl]amino]benzoic acid to give the title compound. Yield 74.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225306B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-69af1d4101e24bf69a70699d4ee62b02 |
| Source note | uspto-grants-2001_05 |