Tetrabutylammonium Fluoride → HCID 59954353, compound

Participants

Reaction Steps

To a solution of (2R,11aS)-2-(tert-butyldimethylsilyloxy)-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one (5.53 g) prepared in Reference Example 68 in tetrahydrofuran (20 ml), there was dropwise added, with ice-cooling, a solution of tetrabutylammonium fluoride (4.54 g) in tetrahydrofuran (50 ml) over 5 minutes and the reaction solution was stirred at room temperature for 30 minutes. After the reaction solution was diluted with ethyl acetate, it was washed with water and then dried over anhydrous magnesium sulfate. The residue obtained after concentration of the reaction solution was subjected to silica gel column chromatography and then eluted with chloroform/acetone (1/1) to give 4.1 g (yield 91.0%) of the title compound.

Provenance & Evidence