4-[(2-phenylbenzoyl)amino]benzoic Acid → HCID 12042762, compound

Participants

Reaction Steps

The same procedures used in Example 25 were repeated using (11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine prepared in Reference Example 28 and 4-[(2-phenylbenzoyl)amino]benzoic acid to give (11aS)-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11, 11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine. The resulting (11aS)-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine was dissolved in ethyl acetate, a 4N hydrochloric acid-ethyl acetate solution was added thereto, the resulting precipitates were recovered through filtration and washed with a small amount of ethyl acetate to thus give the title compound. Yield 62.4%.

Provenance & Evidence