Hydrogen chloride-ethyl acetate → HCID 86756664, compound

Participants

Reaction Steps

The same procedures used in Example 7 were repeated using (2S, 11aR)-2-acetoxy-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine obtained in Example 46 to give (2S, 11aR)-2-hydroxy-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine. The resulting (2S, 11aR)-2-hydroxy-10-[4-[(2-phenylbenzoyl)amino]benzoyl]-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine was dissolved in ethyl acetate, followed by addition of a 4N hydrochloric acid-ethyl acetate solution thereto, removal of the resulting precipitates through filtration and washing them with a small amount of ethyl acetate to give the title compound. Yield 33.2%.

Provenance & Evidence