HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1976266Generated: November 1, 2026
Methanol → Methyl 2,3,4,5-tetrahydro-7-iodo-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate
https://huagongshe.com/reaction/1976266
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Iodine chloride | HCID 24640 | — |
| Reactant | Methyl 2,3,4,5-tetrahydro-3-oxo-4-methyl-1H-1,4-benzodiazepine-2-acetate | HCID 11770765 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2,3,4,5-tetrahydro-7-iodo-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate | HCID 22000810 | 75.5% |
Reaction Steps
Methyl 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (100 g, 0.4 moles) was added to CH2Cl2 (500 ml) plus MeOH (500 ml) and heated at 40° C. for 0.5 hr. The solution was cooled to 26° C. and pyridine (64 g, 0.8 mole) added. Iodine monochloride (71.3 g, 0.44 mole) dissolved in CH2Cl2 (500 ml) was added dropwise over 30 minutes and the reaction stirred for a further 1.0 hr. The product was filtered off, washed with 60/80 petrol and dried in vacuo to yield the title compound (113 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06225465B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-bc26def87d9549458e7bae4b418cb87e |
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| Source note | uspto-grants-2001_05 |
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