Dimethylformamide → HCID 22000905, compound

Participants

Reaction Steps

A mixture of 2,3,5-trimethylphenol (10.0 g), ethyl 4-bromobutyrate (12.6 ml), potassium carbonate (12.2 g), and dimethylformamide (DMF, 100 ml) was stirred at room temperature overnight. The reaction mixture was poured into a mixture of ethyl acetate (AcOEt) and water. The separated organic phase was washed with a saturated aqueous solution of sodium hydrocarbonate (sat. NaHCO3aq.), water, and brine, and was dried over magnesium sulfate (MgSO4). After evaporation, the resulting residue was purified by chromatography over silica gel (CHCl3 as eluent) to give ethyl 4-(2,3,5-trimethylphenoxy)butyrate (16.35 g) as an oil compound.

Provenance & Evidence