反应详情

A mixture of 4-(2,3,5-trimethylphenoxy)butyrate (9.09 g), 1N NaOH (58 ml), and EtOH (80 ml) was stirred at room temperature overnight. The reaction mixture was poured into a mixture of Et2O and water. The separated water phase was washed with Et2O, and was acidified by 6N HCl. After extraction by AcOEt, the AcOEt was washed with water and brine, and dried over MgSO4, and then evaporated. The resulting precipitate was collected by filtration, and dried to give 4-(2,3,5-trimethylphenoxy)butyric acid (4.91 g).

1. washThe separated water phase was washed with Et2O
2. extractionAfter extraction by AcOEt
3. washthe AcOEt was washed with water and brine
4. dry with materialdried over MgSO4
5. customevaporated
6. filtrationThe resulting precipitate was collected by filtration
7. customdried