Chlorosulfonic acid → HCID 22000916, compound

Participants

Reaction Steps

A solution of chlorosulfonic acid (2.79 ml) in dichloromethane (CH2Cl2) (15 ml) was added dropwise to a solution of ethyl (2,5,7,8-tetramethylchroman-2-yl)acetate (2.90 g) in CH2Cl2 (100 ml) at 0-10° C. over an hour. After stirring at room temperature for 5 hours, the reaction mixture was poured into chilled saturated aqueous sodium hydrogen carbonate (sat. aq. NaHCO3). The separated organic phase was washed with sat. aq. NaHCO3, water, and brine, and dried over MgSO4. After filtration, the filtrate was concentrated under reduced pressure to give 2-ethoxycarbonylmethyl-2,5,7,8-tetramethylchroman-6-sulfonyl chloride as a syrup (3.29 g).

Provenance & Evidence