Water → HCID 22000907, compound

Participants

Reaction Steps

A solution of ethyl (2,5,7,8-tetramethylchroman-2-yl)acetate (8.00 g) in tetrahydrofuran (THF) (16 ml) was added dropwise to the suspension of lithium aluminum hydride (1.10 g) in THF (40 ml) under reflux. After refluxing for 2 hours, a solution of water (1 ml) in THF (5 ml) was added to the reaction mixture. The insoluble material was filtered off and the filtrate was concentrated under reduced pressure to give a residue. The residue was purified by chromatography over silica gel (AcOEt-hexane 10:90) to give 2-(2,5,7,8-tetramethylchroman-2-yl)ethanol as a solid (5.00 g).

Provenance & Evidence