HCID 21996968, compound → HCID 21996988, compound

HRID 1976321Notes

Reaction equation

HRID 1976321 reaction equation
BrC1C=CC(O)=C(C=1)C(C1C=CC(C)=CC=1)=O.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([O:34]C)=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([OH:34])=[C:23]([CH:33]=1)[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[O:25]

Participants

3

Reactant 2

HCID 21996968HCID 21996968, compound2×HCID 21996975HCID 21996975, compound2×

Product 1

HCID 21996988HCID 21996988, compound

Procedure

Employing the same general procedure as for the preparation 5-bromo-2-hydroxy-4′-methylbenzophenone (Compound K), 533 mg (1.7 mmol) of 5-bromo-2-methoxy-3′-methylbenzophenone (Compound J) was converted into the title compound using 2.6 mL (2.6 mmol) of boron tribromide (1M in dichloromethane) and 15 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a white solid.

Sources & evidence

ORD record
ord-e0e682dfb3aa442bbeffb9f1fb04c9a9
Source dataset
uspto-grants-2001_05
Patent number
US06225494B1

Reaction notes

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