4-But-2-ynyloxy-benzenesulfonyl chloride → HCID 22222217, compound

HRID 1976389Notes

Reaction equation

HRID 1976389 reaction equation
C([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15]2[CH2:20][CH2:19][S:18][C:17]([CH3:22])([CH3:21])[CH:16]2[C:23]([OH:25])=[O:24])(=[O:14])=[O:13])=[CH:8][CH:7]=1)C#CC.C(OC1C=CC(S(Cl)(=O)=O)=CC=1)C#CC>>[OH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15]2[CH2:20][CH2:19][S:18][C:17]([CH3:21])([CH3:22])[CH:16]2[C:23]([OH:25])=[O:24])(=[O:14])=[O:13])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 111959284-But-2-ynyloxy-benzenesulfonyl chlorideHCID 22644767HCID 22644767, compound

Product 1

HCID 22222217HCID 22222217, compound

Procedure

Alternatively, 4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid may be prepared in 31% yield according to the procedure of Example 36 using 4-but-2-ynyloxy-benzenesulfonyl chloride as the sulfonylating agent.

Sources & evidence

ORD record
ord-bce69d44f37b41a2b40443c987390c4c
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

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