Dichloromethane → HCID 69802348, compound

HRID 1976445Notes

Reaction equation

HRID 1976445 reaction equation
C(OC([NH:8][CH:9]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:16][CH:15]=1)[C:10]([O:12][CH3:13])=[O:11])=O)(C)(C)C.[Cl:28]CCl>>[ClH:28].[ClH:28].[NH2:8][CH:9]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)=[CH:16][CH:15]=1)[C:10]([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 86587125HCID 86587125, compound

Product 1

HCID 69802348HCID 69802348, compoundYield 100%

Procedure

To a solution of methyl [(tert-butoxycarbonyl)amino]{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}acetate was dissolved in dichloromethane, hydrogen chloride gas was bubbled in for 5 minutes. The reaction was then stirred at room temperature for 0.5 h. The solvent was removed to provide 1.80 g of methyl amino{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}acetate dihydrochloride as a light pink solid Yield ˜100%. mp 80° C. (d). Electrospray Mass Spec 279.2 (M+H)+.

Workup

  1. customhydrogen chloride gas was bubbled in for 5 minutes
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-302658487d3f41688a529af4cf5cc7d9
Source dataset
uspto-grants-2001_05
Patent number
US06225311B1

Reaction notes

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