3-Phenyl-2-propyn-1-ol → HCID 57134211, compound

Participants

Reaction Steps

According to the procedure of Step 2 of Example 248, Mitsunobu coupling of 0.345 g (1.0 mmol) of 4-(4-hydroxy-benzenesulfonyl}2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester and 0.159 g (1.2 mmol) of 3-phenyl-2-propyn-1-ol provided 0.254 g (55%) of methyl (3S)-2,2-dimethyl4-({4-[(3-phenyl-2-propynyl)-oxy]phenyl)sulfonyl)-3- thiomorpholine carboxylate as a pale yellow solid. Electrospray Mass Spec: 460.1(M+H)+

Provenance & Evidence