Acetic Anhydride → HCID 69805139, compound

Participants

Reaction Steps

A solution of 1.50 g (3.632 mmol) of methyl (3S)A({[4-(2-butynyloxy)-phenyl]sulfonyl)2,2-dimethyl-thiomorpholine-3-carboxylate-1-oxide in 20 mL of acetic anhydride was heated to reflux for 4h and then concentrated in vacuo. The residue was chromatographed on silica gel eluting with ethyl acetate/hexanes (1:10 ) to provide 0.985 g of methyl(3S)-4-{[4-(2-butynyloxy)phenyl]sulfonyl)-2,2-dimethyl-3,4-dihydro-2H-1,4-thiazine-3-carboxylate as a colorless oil. Electrospray Mass Spec 396.1 (M+H)+.

Provenance & Evidence