Thionyl Chloride → HCID 86756681, compound

HRID 1976526Notes

Reaction equation

HRID 1976526 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:17]=[C:16]([C:18]([OH:20])=O)[CH:15]=[CH:14][C:10]=1[C:11](O)=[O:12])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:23])=O>>[C:1]([N:5]1[C:11](=[O:12])[C:10]2[C:9](=[CH:17][C:16]([C:18]([Cl:23])=[O:20])=[CH:15][CH:14]=2)[S:6]1(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21998540HCID 21998540, compound

Product 1

HCID 86756681HCID 86756681, compound

Procedure

15.0 g of (0.05 mol) of tert-butylsulfamoylterephthalic acid in 95 ml of thionyl chloride were heated under reflux for 8 h. The mixture was concentrated and the residue was triturated with ethyl acetate. This gave 14.6 g (97% of theory) of 2-tert-butylsaccharin-6-carbonyl chloride of m.p. 185-186° C.

Workup

  1. temperatureunder reflux for 8 h
  2. concentrationThe mixture was concentrated
  3. customthe residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-f72ef62464c4438c88c84c503e4edfd8
Source dataset
uspto-grants-2001_05
Patent number
US06228808B1

Reaction notes

Loading…