反应详情

Similarly to Examples A5 to A6, and using ammonia as basic reagent in Example A5, methyl 2-tert-butylsulfamoyl-4-carbamoylbenzoate was prepared first. At room temperature, 3.0 g (0.01 mol) of this compound were subsequently added to a solution of 45 g (1.0 mol) of dimethylamine in 60 ml of methanol, and the reaction mixture was left standing at room temperature for 7 h. The mixture was concentrated and the desired product was isolated by silica gel column chromatography (mobile phase: ethyl acetate; Rf≈0.2). This gave 1.0 g (31% of theory) of N,N-dimethyl-2-tert-butylsulfamoyl-4-carbamoylbenzamide of a glass-like consistency.

1. customwas prepared first
2. waitthe reaction mixture was left
3. concentrationThe mixture was concentrated