HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1976533Generated: October 30, 2026
Thionyl Chloride → 2-Chloronicotinoyl chloride
https://huagongshe.com/reaction/1976533
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Product | 2-Chloronicotinoyl chloride | HCID 2774541 | 100.6% |
Reaction Steps
1131 g (9.5 mol) of thionyl chloride were slowly added dropwise at 90° C. to 500 g (3.17 mol) of 2-chloronicotinic acid. The reaction mixture was stirred for 1 hour at 90° C. and freed from thionyl chloride under reduced pressure (“high vacuum”) at approximately 40° C. This gave 561 g (100%) of the title compound as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06228810B1 |
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| Source dataset | uspto-grants-2001_05 |
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| ORD ID | ord-66af3623d69f4f39b65bd25a25ba35a9 |
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| Source note | uspto-grants-2001_05 |
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