Methanol → HCID 178490828, compound

Participants

Reaction Steps

A solution of 6-amino-8-(1-benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy-4-methoxy-benzyl)-3H-purine hydrochloride (2.13 g, 4.06 mmole), in THF:methanol,1:1 (60 ml), was hydrogenated at room temperature and pressure with 10% Pd-C (0.26 g) for 12 hours. The catalyst was filtered off and the solvents removed in vacuo. The residue was suspended in hot acetone, the solid collected at 0-5° C. (1.23 g) and recrystallized from methanol-acetone to give the title compound, 0.76 g (43.2%) mp 231-232° C.

Provenance & Evidence