HCID 178490826, compound → HCID 178490829, compound

Participants

Reaction Steps

A solution of the above 6-amino-3-(3-benzyloxy-4-methoxy-benzyl)-8-(1-benzyloxy-1-methyl-ethyl)-3H-purine hydrochloride (3.22 g) in THF:methanol (1:1) (60 ml) was hydrogenated at room temperature and pressure for 2.5 hours with 10% Pd-C (0.64 g). The catalyst was filtered off and the solution evaporated to dryness in vacuo. The residue was crystallized from acetone to give 6-amino-3-(3-hydroxy-4-methoxy-benzyl)-8-(1-hydroxy-1-methyl-ethyl)-3H-purine hydrochloride, (1.67 g, 77.3%) mp 155-160° C.

Provenance & Evidence